Uses of Rye (ergot)
Ergot, Rye ergot or secale cornutum is the dried sclerotium of Claviceps purpurea (Fam. Hypocreaceae) developed on plants of Rye Secale cereale (Fam. Gramineae)
Ergot is the sclerotium of fungus (Claviceps purpurea) which develops on Rye plant (Secale cereale)
A sclerotium (plural sclerotia) is a compact mass of hardened fungal mycelium containing food reserves Ergot is dark purple colored
Alkaloids (not less than 0.15%)
- Mixture of ergocristine, ergokryptine and eregocornine
Uses of Ergot:
Ergot is a source of ergotamine which is used to treat migraine
Dihydroergotamine, a semisynthetic analog of ergotamine, prepared by hydrogenation of the double bond in the lysergic acid nucleus. It is more effective and better tolerated than ergotamine
Ergot is a source of ergonovine which is used for the prevention and treatment of
- postpartum (occurring in or relating to the period immediately after childbirth)
- hemorrhage caused by uterine atony (lack of normal muscle tone)
Methylergonovine, a semisynthetic homolog of ergonovine, is slightly more active and long lasting than ergonovine
Ergotoxine (ergocristine+ergokryptine+eregocornine), a mixture of equal parts of these component alkaloids is hydrogenated to eliminate the double bond of lysergic acid nucleus and to yield an equivalent mixture of dihydroergocristine, dihydroergokryptine and dihydroeregocornine
This mixture is used to treat selected symptoms in elderly patients
They produce vasorelaxation, increased cerebral blood flow, lowering of systemic blood pressure and bradycardia.
Methysergide maleate is a salt of methylergonovine
It is a serotonin antagonist, used in the prophylaxis of vascular headache LSD, doesn’t occur in nature. It is prepared by semi-synthesis
It has 2-fold action
Produces a predominant central sympathetic stimulation that parallels a slight depression • It is the most active psychotomimetic agent known
LSD is of considerable interest and value in experimental psychiatry
The drug is available only to qualified scientific investigators.
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