Uses of Rye

Uses of Rye (ergot)

Ergot, Rye ergot or secale cornutum is the dried sclerotium of Claviceps purpurea (Fam. Hypocreaceae) developed on plants of Rye Secale cereale (Fam. Gramineae)

Ergot is the sclerotium of fungus (Claviceps purpurea) which develops on Rye plant (Secale cereale)

A sclerotium (plural sclerotia) is a compact mass of hardened fungal mycelium containing food reserves Ergot is dark purple colored

Constituents

Alkaloids (not less than 0.15%)

  • Ergonovine
  • Ergotamine
  • Mixture of ergocristine, ergokryptine and eregocornine

Uses of Ergot:

Ergot is a source of ergotamine which is used to treat migraine

Dihydroergotamine, a semisynthetic analog of ergotamine, prepared by hydrogenation of the double bond in the lysergic acid nucleus. It is more effective and better tolerated than ergotamine

Ergot is a source of ergonovine which is used for the prevention and treatment of

  • postpartum (occurring in or relating to the period immediately after childbirth)
  • hemorrhage caused by uterine atony (lack of normal muscle tone)

Methylergonovine, a semisynthetic homolog of ergonovine, is slightly more active and long lasting than ergonovine

Ergotoxine (ergocristine+ergokryptine+eregocornine), a mixture of equal parts of these component alkaloids is hydrogenated to eliminate the  double bond of lysergic acid nucleus and to yield an equivalent mixture of dihydroergocristine, dihydroergokryptine and dihydroeregocornine

This mixture is used to treat selected symptoms in elderly patients

They produce vasorelaxation, increased cerebral blood flow, lowering of systemic blood pressure and bradycardia.

Methysergide maleate is a salt of methylergonovine

It is a serotonin antagonist, used in the prophylaxis of vascular headache LSD, doesn’t occur in nature. It is prepared by semi-synthesis

It has 2-fold action

Produces a predominant central sympathetic stimulation that parallels a slight depression • It is the most active psychotomimetic agent known

LSD is of considerable interest and value in experimental psychiatry

The drug is available only to qualified scientific investigators.

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